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Most cancers that develop in the uterus start in the endometrium, the lining tissue, and are collectively known as endometrial cancer, the most common gynecologic cancer in many parts of the world. Uterine sarcoma is a much rarer and biologically distinct cancer that instead arises from the muscular wall of the uterus or its supporting connective tissue, and it tends to behave more aggressively, spread more readily, and respond less predictably to standard treatments than typical endometrial cancer.
Because uterine sarcoma is uncommon and its early symptoms overlap considerably with far more frequent, benign uterine conditions such as fibroids, it is often not suspected until surgery, sometimes performed for a presumed benign reason, reveals the true diagnosis.
